Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.54 |
| ▸ | BRD4 | O60885 | 3/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059320 | 0.77 | CREBBP (0.45) | CREBBPBRD4MAPTALDH1A1HTT | |
| SCHEMBL9559115 | 0.74 | CREBBP (0.43) | CREBBPBRD4PDE4APDE4BPDE4C | |
| SCHEMBL339812 | 0.74 | MAPT (0.71) | BRD4HTR1ASLC6A2SLC6A3MAPT | |
| SCHEMBL27767020 | 0.73 | MAOB (0.56) | CREBBPBRD4TNKS2SLC6A2SLC6A3 | |
| SCHEMBL5207455 | 0.73 | MAOB (0.56) | CREBBPBRD4TNKS2SLC6A2SLC6A3 | |
| Formaldehyde SCHEMBL27831678 | 0.72 | MAPT (0.63) | BRD4HTR1AMAPTMAPK1TDP1 | |
| SCHEMBL7360048 | 0.71 | ALOX5 (0.50) | CREBBPBRD4SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL17680774 | 0.71 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL10702878 | 0.70 | BRD4 (0.47) | CREBBPBRD4SLC6A2SLC6A3MAPK1 | |
| SCHEMBL23258867 | 0.69 | MAPT (0.59) | BRD4HTR1AMAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |