Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | MPC2 | O95563 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LPO | P22079 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809640 | 0.93 | CA2 (0.49) | CA2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8810910 | 0.90 | PPARG (0.52) | CA2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8811288 | 0.89 | CA2 (0.51) | CA2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8808817 | 0.88 | PTPN1 (0.51) | CA2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8811861 | 0.87 | MAOA (0.47) | CA2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8813904 | 0.87 | CA2 (0.66) | CA2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8809456 | 0.87 | CA2 (0.57) | CA2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8685830 | 0.86 | PPARG (0.47) | CA2PPARGFFAR1MAPTPPARA | |
| SCHEMBL8810651 | 0.85 | MPO (0.46) | PPARGFFAR1SLC2A1LMNAPPARA | |
| SCHEMBL8812021 | 0.84 | FFAR1 (0.52) | CA2PPARGMPC2CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1167111-A | Thiazolidinedione derivatives, method for preparing derivatives and pharmaceutical compositions containing same | SENGA PHARMACEUTICAL LAB INC (JP) | 1997-12-10 | — | — | CN | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |