Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346840 | 0.83 | POLB (0.47) | HTTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8343053 | 0.80 | BCHE (0.35) | BCHEBACE1ACHESLC6A12SIGMAR1 | |
| SCHEMBL8346429 | 0.77 | DRD3 (0.37) | SLC6A12HTTMEN1KMT2AKDM4E | |
| SCHEMBL8727530 | 0.77 | MEN1 (0.43) | MEN1KMT2AKDM4EPDCD1CD274 | |
| SCHEMBL8661019 | 0.73 | LMNA (0.38) | OPRM1BCHEBACE1ACHESLC6A12 | |
| SCHEMBL4344742 | 0.73 | CHRM2 (0.34) | BCHEBACE1ACHESLC6A12SIGMAR1 | |
| SCHEMBL8659952 | 0.72 | ALDH1A1 (0.35) | SLC6A12HTTMEN1KMT2ASLC6A1 | |
| SCHEMBL6855484 | 0.72 | SLC6A2 (0.32) | OPRK1 | |
| SCHEMBL8343429 | 0.72 | CHRNB4 (0.41) | OPRK1OPRM1BCHEBACE1ACHE | |
| SCHEMBL8660379 | 0.72 | SLC6A1 (0.34) | OPRM1SLC6A12MEN1KMT2ASLC6A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739335-A4 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS INC (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0739335-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018792-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |