Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14925281 | 0.79 | KMT2A (0.46) | KMT2ATSHRMEN1HTTALDH1A1 | |
| SCHEMBL11220698 | 0.76 | KMT2A (0.50) | KMT2ATSHRMEN1HTTALDH1A1 | |
| SCHEMBL31003335 | 0.74 | ALDH1A1 (0.67) | KMT2AMEN1HTTALDH1A1HPGD | |
| SCHEMBL1539315 | 0.74 | ALDH1A1 (0.67) | KMT2AMEN1HTTALDH1A1HPGD | |
| SCHEMBL5315078 | 0.74 | CES2 (0.47) | HTTALDH1A1HPGDCYP3A4KEAP1 | |
| SCHEMBL9020581 | 0.74 | CA12 (0.42) | KMT2ATSHRMEN1HTTALDH1A1 | |
| SCHEMBL3604278 | 0.73 | POLB (0.42) | KMT2ATSHRMEN1HTTKEAP1 | |
| SCHEMBL10413873 | 0.73 | KMT2A (0.71) | KMT2ATSHRMEN1HTTALDH1A1 | |
| SCHEMBL7412320 | 0.72 | HTT (0.43) | KMT2ATSHRMEN1HTTALDH1A1 | |
| SCHEMBL23139862 | 0.71 | HTT (0.56) | KMT2AMEN1HTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997013750-A1 | AZETIDINONES AND THEIR THERAPEUTIC USE AS CYTOKINE INHIBITORS | CHIROSCIENCE LIMITED (GB) | 1997-04-17 | — | — | WO | disclosed |