Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1C | P00326 | 2/20 | 0.40 |
| ▸ | ADH1A | P07327 | 2/20 | 0.40 |
| ▸ | ADH4 | P08319 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.34 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.34 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | ADH1B | P00325 | 1/20 | 0.31 |
| ▸ | ADH7 | P40394 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11382184 | 0.98 | ADH1C (0.43) | ADH1CADH1AADH4TSHRALDH1A1 | |
| SCHEMBL9067688 | 0.98 | ADH1C (0.43) | ADH1CADH1AADH4TSHRALDH1A1 | |
| SCHEMBL11381246 | 0.94 | TSHR (0.37) | ADH1CADH1AADH4TSHRALDH1A1 | |
| SCHEMBL11374158 | 0.85 | — | — | |
| SCHEMBL97181 | 0.82 | ADH1C (0.48) | ADH1CADH1AADH4TSHRALDH1A1 | |
| SCHEMBL95389 | 0.80 | ADH1C (0.52) | ADH1CADH1AADH4TSHRFAAH | |
| SCHEMBL55195 | 0.80 | ADH1C (0.52) | ADH1CADH1AADH4TSHRFAAH | |
| SCHEMBL3962903 | 0.80 | ADH1C (0.52) | ADH1CADH1AADH4TSHRFAAH | |
| SCHEMBL277587 | 0.80 | ADH1C (0.52) | ADH1CADH1AADH4TSHRFAAH | |
| SCHEMBL271668 | 0.80 | ADH1C (0.47) | ADH1CADH1AADH4TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1474 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611300-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | Bayer Intellectual Property GmbH (DE) | 2013-07-10 | — | — | EP | claimed |
| US-8273740-B2 | antiallergen; not direct way to change nature of immunological response to allergen; G-protein-coupled \"chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)\" antagonist for prostaglandin PGD2, that mediates PGD2-dependent migration of blood Th2 cells; ; asthma, rhinitis, COPD | ACTELION PHARMACEUTICALS, LTD. (CH) | 2012-09-25 | — | — | US | claimed |
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | BAYER CROPSCIENCE AG (DE) | 2012-06-21 | — | — | US | claimed |
| US-20120094987-A1 | SUBSTITUTED PYRIDO [3', 2': 4, 5] THIENO [3, 2-D] PYRIMIDINES AND PYRIDO [3', 2': 4, 5] FURO [3, 2-D] PYRIMIDINES USED AS INHIBITORS OF THE PDE-4 AND/OR THE RELEASE OF TNF-alpha | CURACYTE DISCOVERY GMBH (DE) | 2012-04-19 | — | — | US | claimed |
| WO-2012028578-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER CROPSCIENCE AG (DE) | 2012-03-08 | — | — | WO | claimed |
| US-8088796-B2 | Triamine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-01-03 | — | — | US | claimed |
| US-8058285-B2 | Phosphodiesterase-4 (PDE-4) inhibitors; for treating bronchial asthma, COPD, rheumatoid arthritis (RA), osteoarthritis, cystic fibrosis, Guillain-Barresyndrome, Crohn's disease, ulcerative colitis, psoriasis, atopic dermatitis, allergic eczemas | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-11-15 | — | — | US | claimed |
| US-20100113770-A1 | O-SUBSTITUTED HYDROXYARYL DERIVATIVES | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2010-05-06 | — | — | US | claimed |
| EP-1773840-B1 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINES AND PYRIDO[3',2':4,5]FURO[3,2-D]-PYRIMIDINES FOR USE AS INHIBITORS OF PDA-4 AND/OR TNF-ALPHA RELEASE | MEDICINES CO LEIPZIG GMBH (DE) | 2010-01-20 | — | — | EP | claimed |
| US-20090239857-A1 | TRIAMINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-09-24 | — | — | US | claimed |
| WO-1990009369-A1 | BENZOTRIAZOLE AND OXANILIDE UV ABSORBER HYDRAZIDES | ATOCHEM NORTH AMERICA, INC. (US) | 1990-08-23 | — | — | WO | claimed |
| EP-0281891-A2 | Dye builders, their preparation and use | BAYER AG (DE) | 1988-09-14 | — | — | EP | claimed |
| EP-0185240-A2 | Process for the preparation of N-substituted benz[c,d]indol-2-ones | BAYER AG (DE) | 1986-06-25 | — | — | EP | claimed |
| EP-0181852-A1 | Substituted 2,6-substituted pyridine compounds | Monsanto Company (US) | 1986-05-21 | — | — | EP | claimed |
| EP-0167820-A2 | Process for the preparation of optionally substituted benz(c,d)-indol-2-ones (naphtholactames) | BAYER AG (DE) | 1986-01-15 | — | — | EP | claimed |
| US-4297440-A | CONTAINING A 3-ANILINO-5-PYRAZOLONE MAGENTA COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1981-10-27 | — | — | US | claimed |
| US-4275200-A | CONDENSATION OF CARBAMIC ESTERS WITH X-HALOGEN CARBONYL COMPOUNDS | AGFA-GEVAERT, A.G. (DE) | 1981-06-23 | — | — | US | claimed |
| US-4191576-A | SULFONYL-SUBSTITUTED PYRROLIDINE, OXAZOLIDINE OR THIAZOLIDINE | FUJI PHOTO FILM CO., LTD. (JP) | 1980-03-04 | — | — | US | claimed |
| US-4032346-A | 5-OXO-2-PYRAZOLIN-4-YL-AMINE-CARBODITHIOATE-DITHIOCARBONATE | FUJI PHOTO FILM CO., LTD. (JA) | 1977-06-28 | — | — | US | claimed |
| US-3980430-A | CATIONIC DYE, HALOGENATED HYDROCARBON | BAYER AKTIENGESELLSCHAFT (DT) | 1976-09-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239857-A1 | TRIAMINE DERIVATIVE | F2, F12, F3 | ADH1C 2332/4885ADH1A 1033/4885ADH4 1900/4885 |
| US-20120094987-A1 | SUBSTITUTED PYRIDO [3', 2': 4, 5] THIENO [3, 2-D] PYRIMIDINES AND PYRIDO [3', 2': 4, 5] FURO [3, 2-D] PYRIMIDINES USED AS INHIBITORS OF THE PDE-4 AND/OR THE RELEASE OF TNF-alpha | PDE4A, PDE4B, PDE3B | ADH1C 714/4885ADH1A 998/4885ADH4 546/4885 |
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | DHPS, FDPS, DPYD | ADH1C 260/4885ADH1A 444/4885ADH4 220/4885 |
| US-20100113770-A1 | O-SUBSTITUTED HYDROXYARYL DERIVATIVES | RELA, NFKBIA, NFE2 | ADH1C 1340/4885ADH1A 386/4885ADH4 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.