Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810609 | 1.00 | DRD2 (0.39) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL1389028 | 0.85 | DRD4 (0.41) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL1389027 | 0.85 | DRD4 (0.41) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8303355 | 0.74 | DRD2 (0.49) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8303352 | 0.74 | DRD2 (0.49) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8303694 | 0.71 | DRD2 (0.46) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8299061 | 0.71 | DRD2 (0.46) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8429501 | 0.69 | KDM4E (0.64) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| SCHEMBL8429503 | 0.69 | KDM4E (0.64) | DRD2DRD4DRD3KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8428835 | 0.68 | KDM4E (0.66) | DRD2DRD4DRD3KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717733-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |