Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AGT | P01019 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812898 | 0.83 | MAP4K4 (0.42) | HRH3POLBBCHEACHEBACE1 | |
| SCHEMBL9093218 | 0.82 | AGTR1 (0.48) | AGTR1AGTR2MEN1KMT2ACD274 | |
| SCHEMBL9024777 | 0.78 | AGTR1 (0.51) | AGTR1AGTR2AKT1AGT | |
| SCHEMBL30316147 | 0.78 | AGTR1 (0.51) | AGTR1AGTR2AKT1AGT | |
| SCHEMBL3950499 | 0.78 | AGTR1 (0.44) | AGTR1AGTR2HRH3AGT | |
| SCHEMBL8532808 | 0.78 | AGTR1 (0.51) | AGTR1AGTR2HRH3MEN1KMT2A | |
| SCHEMBL8246839 | 0.77 | AGTR1 (0.50) | AGTR1AGTR2AGTPOLB | |
| SCHEMBL4246354 | 0.77 | AGTR1 (0.50) | AGTR1AGTR2HRH3AKT1AGT | |
| SCHEMBL29404889 | 0.77 | AGTR1 (0.50) | AGTR1AGTR2AGTPOLB | |
| SCHEMBL13146764 | 0.77 | AGTR1 (0.55) | AGTR1AGTR2AGT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |