Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813574 | 0.83 | AGTR1 (0.47) | ACHEBACE1POLBHRH3BCHE | |
| SCHEMBL8814155 | 0.80 | ALDH1A1 (0.51) | MAP4K4ACHEBACE1CARM1PRMT6 | |
| SCHEMBL8809135 | 0.76 | MAP4K4 (0.45) | MAP4K4ACHEBACE1CARM1PRMT6 | |
| SCHEMBL8807848 | 0.75 | HRH3 (0.62) | MAP4K4ACHEBACE1CARM1PRMT6 | |
| SCHEMBL976147 | 0.72 | LMNA (0.47) | POLBALDH1A1 | |
| SCHEMBL8811824 | 0.71 | ALDH1A1 (0.48) | MAP4K4CARM1PRMT6POLBKCNH2 | |
| SCHEMBL9057690 | 0.71 | AGTR1 (0.38) | ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7611179 | 0.71 | MAOA (0.43) | POLBALDH1A1 | |
| SCHEMBL9252404 | 0.69 | ALDH1A1 (0.68) | POLBKCNH2ALDH1A1PARP1HRH3 | |
| SCHEMBL11509945 | 0.69 | ALDH1A1 (0.68) | POLBKCNH2ALDH1A1PARP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |