Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | CTSD | P07339 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8816740 | 0.90 | TSHR (0.56) | TSHRMAPK1LMNAALDH1A1HPGD | |
| Ammonia Solution, Strong SCHEMBL8813652 | 0.83 | TSHR (0.53) | TSHRMAPK1LMNAALDH1A1CXCR3 | |
| SCHEMBL6566519 | 0.78 | MAPK1 (0.69) | TSHRMAPK1LMNAALDH1A1HPGD | |
| SCHEMBL6099527 | 0.77 | TSHR (0.53) | TSHRMAPK1LMNAALDH1A1CXCR3 | |
| SCHEMBL9633041 | 0.77 | RAB9A (0.60) | TSHRMAPK1LMNAALDH1A1HPGD | |
| SCHEMBL8815820 | 0.75 | LMNA (0.51) | TSHRMAPK1LMNAALDH1A1CXCR3 | |
| SCHEMBL15693964 | 0.74 | ALDH1A1 (0.55) | TSHRMAPK1LMNAALDH1A1HPGD | |
| SCHEMBL30960133 | 0.74 | TSHR (0.75) | TSHRMAPK1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL29227699 | 0.74 | TSHR (0.75) | TSHRMAPK1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL9340035 | 0.74 | TSHR (0.50) | TSHRMAPK1LMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997011052-A1 | UREA DERIVATIVES AND THEIR USE AS ANALGESICS AND ANTIINFLAMMATORY AGENTS | NOVARTIS AG (CH) | 1997-03-27 | — | — | WO | disclosed |