Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8927569 | 0.92 | DGAT1 (0.53) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8814492 | 0.91 | DGAT1 (0.48) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8814915 | 0.90 | DGAT1 (0.51) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8926249 | 0.90 | DGAT1 (0.51) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8931691 | 0.89 | DGAT1 (0.53) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8931698 | 0.89 | DGAT1 (0.56) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8931761 | 0.88 | DGAT1 (0.54) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8931121 | 0.87 | DGAT1 (0.53) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7878336 | 0.87 | DGAT1 (0.53) | DGAT1MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8931650 | 0.87 | DGAT1 (0.51) | DGAT1MAPTALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770073-A1 | ANTI-HELICOBACTER HETEROCYCLIC DERIVATIVES OF AZOLONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-02 | — | — | EP | disclosed |
| US-5607932-A | Heterocyclic derivatives of azolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-04 | — | — | US | disclosed |
| WO-1996001821-A1 | ANTI-HELICOBACTER HETEROCYCLIC DERIVATIVES OF AZOLONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-01-25 | — | — | WO | disclosed |