SCHEMBL8816645

SCHEMBL8816645

COc1nn(C)c(=O)n1-c1ccccc1Oc1nc(-c2cc(Cl)sc2Cl)ns1

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
RAB9A P51151 1/20 0.32
BRD4 O60885 1/20 0.31
THRB P10828 1/20 0.30
ALPL P05186 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8595988 0.83 EIF4E (0.35) LMNASMN1; SMN2RAB9ATHRB
SCHEMBL8595340 0.80 RORB (0.34) LMNASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL8810747 0.80 MEN1 (0.32) LMNASMN1; SMN2
SCHEMBL8590947 0.79 DHPS (0.37) LMNASMN1; SMN2THRB
SCHEMBL8811476 0.79 MAPT (0.38) LMNASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL8524457 0.78 SMN1; SMN2 (0.34) LMNASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL8550685 0.76 PSEN1 (0.36)
SCHEMBL8815698 0.75 LMNA (0.32) LMNASMN1; SMN2THRB
SCHEMBL8596743 0.74 FAAH (0.33) LMNABRD4
SCHEMBL8484212 0.69 SMN1; SMN2 (0.47) LMNASMN1; SMN2ALDH1A1RAB9ABRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997000612-A1 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-01-09 WO disclosed