SCHEMBL8817014

SCHEMBL8817014

O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)NC1CCCCC1)OCc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.58
CTSL P07711 3/20 0.58
ALDH1A1 P00352 2/20 0.57
TACR1 P25103 2/20 0.54
HDAC1 Q13547 1/20 0.54
HDAC2 Q92769 1/20 0.54
CTSK P43235 3/20 0.53
KDM4E B2RXH2 1/20 0.53
CTSB P07858 2/20 0.53
CTSS P25774 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8817011 1.00 EPHX1 (0.58) EPHX1CTSLALDH1A1TACR1HDAC1
SCHEMBL10706018 0.94 CTSL (0.64) EPHX1CTSLALDH1A1TACR1HDAC1
SCHEMBL10724240 0.81 TACR1 (0.61) CTSLALDH1A1TACR1CTSKCTSB
SCHEMBL10724242 0.81 TACR1 (0.61) CTSLALDH1A1TACR1CTSKCTSB
SCHEMBL10724879 0.81 TACR1 (0.61) CTSLALDH1A1TACR1CTSKCTSB
SCHEMBL10724885 0.81 TACR1 (0.61) CTSLALDH1A1TACR1CTSKCTSB
SCHEMBL7291131 0.81 GPR34 (0.63) CTSLALDH1A1TACR1CTSKCTSB
SCHEMBL8258487 0.81 GPR34 (0.63) CTSLALDH1A1TACR1CTSKCTSB
SCHEMBL10722503 0.81 GPR34 (0.63) CTSLALDH1A1TACR1CTSKCTSB
SCHEMBL2511842 0.81 GPR34 (0.63) CTSLALDH1A1TACR1CTSKCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997019908-A1 PHENYLALANINE DERIVATIVES, OPTICALLY ACTIVE SUBSTANCES, SALTS OR COORDINATION COMPOUNDS THEREOF, AND THEIR USE AS FUNGICIDES NIHON NOHYAKU CO., LTD. (JP) 1997-06-05 WO disclosed