Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | SI | P14410 | 5/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 5/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8816591 | 0.88 | NR1I3 (0.50) | PTGESMGAMGAASIMGAM2 | |
| SCHEMBL8818778 | 0.85 | GAA (0.49) | PTGESMGAMGAASIMGAM2 | |
| SCHEMBL8818927 | 0.84 | MGAM (0.41) | PTGESMGAMGAASIMGAM2 | |
| SCHEMBL8814849 | 0.80 | PARP1 (0.49) | MGAMGAASIMGAM2DHODH | |
| SCHEMBL8816563 | 0.80 | DHODH (0.40) | MGAMGAASIMGAM2DHODH | |
| SCHEMBL8077963 | 0.80 | MAP4K4 (0.49) | PTGESMGAMGAASIMGAM2 | |
| SCHEMBL8818534 | 0.79 | PTGES (0.38) | PTGESMGAMGAASIMGAM2 | |
| SCHEMBL8077969 | 0.79 | CHEK2 (0.45) | PTGESMGAMGAASIMGAM2 | |
| SCHEMBL29056652 | 0.74 | PTGES (0.56) | PTGESMGAMGAASIMGAM2 | |
| SCHEMBL8817558 | 0.74 | MGAM (0.51) | PTGESMGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997033873-A1 | METHODS OF TREATING OR PREVENTING INTERSTITIAL CYSTITIS | ELI LILLY AND COMPANY (US) | 1997-09-18 | — | — | WO | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |