Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PPIA | P62937 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669597 | 0.79 | KMT2A (0.54) | ALDH1A1MAPTADRA1APOLBKMT2A | |
| Sulfamethoxazole SCHEMBL3656 | 0.79 | ALDH1A1 (1.00) | ALDH1A1MAPTADRA1AKMT2ATSHR | |
| Sulfamethoxazole SCHEMBL6896861 | 0.79 | ALDH1A1 (1.00) | ALDH1A1MAPTADRA1AKMT2ATSHR | |
| SCHEMBL6669173 | 0.78 | SCN1A (0.48) | ALDH1A1MAPTADRA1APOLBKMT2A | |
| SCHEMBL6667913 | 0.78 | POLB (0.44) | ALDH1A1MAPTADRA1APOLBKMT2A | |
| SCHEMBL6668334 | 0.78 | TSHR (0.48) | ALDH1A1MAPTADRA1APOLBKMT2A | |
| SCHEMBL6670578 | 0.78 | HTT (0.49) | ALDH1A1MAPTADRA1APOLBKMT2A | |
| Sulfamethoxazole SCHEMBL5870744 | 0.77 | ALDH1A1 (0.97) | ALDH1A1MAPTADRA1AKMT2ATSHR | |
| Sulfamethoxazole SCHEMBL28501919 | 0.77 | ALDH1A1 (0.97) | ALDH1A1MAPTADRA1AKMT2ATSHR | |
| Sulfamethoxazole SCHEMBL22467841 | 0.77 | ALDH1A1 (0.97) | ALDH1A1MAPTADRA1AKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066441-C | Phenyl sulfonamide endothelin antagonists | SQUIBB & SONS INC (US) | 2001-05-30 | — | — | CN | claimed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | claimed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | claimed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |