Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21164589 | 0.88 | SLC22A1 (0.47) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL27508911 | 0.86 | HIF1A (0.50) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL24372163 | 0.85 | OPRM1 (0.45) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL882235 | 0.84 | OPRM1 (0.55) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL12438398 | 0.84 | OPRM1 (0.55) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL24406297 | 0.84 | OPRM1 (0.55) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL1634407 | 0.84 | GABBR2 (0.46) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL2499542 | 0.84 | GABBR2 (0.46) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL2500898 | 0.84 | GABBR2 (0.46) | HIF1ALMNAGALR3OPRM1SLC22A1 | |
| SCHEMBL30656282 | 0.84 | LMNA (0.42) | HIF1ALMNAGALR3OPRM1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10946018-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | ROIVANT SCIENCES GMBH (CH) | 2021-03-16 | — | — | US | disclosed |
| US-20200237760-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | ROIVANT SCIENCES GMBH (CH) | 2020-07-30 | — | — | US | disclosed |
| WO-2018144649-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | Arvinas, Inc. (US) | 2018-08-09 | — | — | WO | disclosed |
| US-9750740-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | Kanos Pharmaceuticals, Inc. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20170095476-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2017-04-06 | — | — | US | disclosed |
| US-8293715-B2 | 10a-Azalide compound crosslinked at 10a- and 12-positions | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-10-23 | — | — | US | disclosed |
| US-20110237784-A1 | 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
| EP-2177526-A1 | 10A-AZALIDE COMPOUND CROSSLINKED AT POSITION-10A AND POSITION-12 | Taisho Pharmaceutical Co. Ltd. (JP) | 2010-04-21 | — | — | EP | disclosed |
| WO-1995025083-A1 | PROCESS FOR THE PREPARATION OF ARYL HALOFORMATES AND DIARYL CARBONATES | GALVAN, RAFAEL | 1995-09-21 | — | — | WO | disclosed |
| US-5424473-A | Process for the preparation of aryl haloformates and diaryl carbonates | THE DOW CHEMICAL COMPANY (US) | 1995-06-13 | — | — | US | disclosed |
| US-4390710-A | A 4-AMINOPYRIDINE WITH A PYRIDINE | PPG INDUSTRIES, INC. (US) | 1983-06-28 | — | — | US | disclosed |
| EP-0040741-B1 | PROCESS FOR THE PREPARATION OF CHLOROFORMIC-ACID ARYL ESTERS | BAYER AG (DE) | 1983-06-08 | — | — | EP | disclosed |
| US-4366102-A | Process for the preparation of chloroformic acid aryl esters | BAYER AKTIENGESELLSCHAFT (DE) | 1982-12-28 | — | — | US | disclosed |
| EP-0040741-A1 | Process for the preparation of chloroformic-acid aryl esters | BAYER AG (DE) | 1981-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237784-A1 | 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS | DCLRE1A, AZI2, CHD9 | HIF1A 2415/4885LMNA 1834/4885GALR3 3418/4885 |
| US-20200237760-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | TPH1, TPH2, HTR1A | HIF1A 851/4885LMNA 2851/4885GALR3 2083/4885 |
| US-20170095476-A1 | SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | TPH1, TPH2, HTR1A | HIF1A 851/4885LMNA 2851/4885GALR3 2083/4885 |
| US-10946018-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | TPH1, TPH2, HTR1A | HIF1A 851/4885LMNA 2851/4885GALR3 2083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.