Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5563575 | 0.92 | HIF1A (0.50) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL2383072 | 0.88 | HIF1A (0.53) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL8400500 | 0.86 | HIF1A (0.45) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL24406297 | 0.84 | OPRM1 (0.55) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL12438398 | 0.84 | OPRM1 (0.55) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL882235 | 0.84 | OPRM1 (0.55) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL27739296 | 0.83 | DRD3 (0.43) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL2501602 | 0.82 | FFAR1 (0.46) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL2498459 | 0.82 | FFAR1 (0.46) | SLC22A1OPRM1HIF1ALMNAGALR3 | |
| SCHEMBL11619633 | 0.81 | OPRM1 (0.54) | SLC22A1OPRM1HIF1ALMNAGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350208-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | ROIVANT SCIENCES GMBH (CH) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350208-B2 | Spirocyclic compounds as tryptophan hydroxylase inhibitors | TPH1, TPH2, HTR1A | SLC22A1 526/4885OPRM1 511/4885HIF1A 851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.