Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8823363 | 0.93 | KMT2A (0.49) | ALDH1A1KMT2ALMNAPOLBMEN1 | |
| SCHEMBL7827049 | 0.87 | MAPT (0.45) | ALDH1A1KMT2APOLBMEN1SMN1; SMN2 | |
| SCHEMBL812289 | 0.84 | MAPT (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8392375 | 0.83 | MAPT (0.44) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL7827231 | 0.82 | LDHA (0.44) | ALDH1A1KMT2APOLBSMN1; SMN2MAPT | |
| SCHEMBL7825644 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KMT2ALMNAPOLBMEN1 | |
| SCHEMBL8823362 | 0.76 | LDHA (0.46) | POLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL6627953 | 0.76 | ALDH1A1 (0.70) | ALDH1A1KMT2ALMNAPOLBMEN1 | |
| SCHEMBL9670773 | 0.75 | ALDH1A1 (0.41) | ALDH1A1KMT2ALMNAPOLBMEN1 | |
| SCHEMBL8400177 | 0.75 | L3MBTL1 (0.38) | ALDH1A1KMT2ALMNAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534363-B1 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5529996-A | USEFUL FOR CONGESTIVE HEART FAILURE, DIURETIC EFFECT, IRRITABLE BOWL MOVEMENT, ENDORPHIN OR ENKEPHALIN MEDIATED ANALGESIC EFFECTS AND ALSO HYPOTENSIVE AGENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5486513-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors or enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-23 | — | — | US | disclosed |
| US-5428158-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0534363-A2 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |