Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.63 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325622 | 0.98 | ALDH1A1 (0.68) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL5844682 | 0.90 | BACE1 (0.61) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL14100444 | 0.85 | SIGMAR1 (0.60) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL19743237 | 0.85 | KCNH2 (0.60) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL27780880 | 0.84 | SIGMAR1 (0.67) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL5230894 | 0.84 | SIGMAR1 (0.74) | KMT2AMAPK1KCNH2SIGMAR1POLB | |
| SCHEMBL4202978 | 0.84 | SIGMAR1 (0.65) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL2425554 | 0.80 | SIGMAR1 (0.78) | KMT2AMAPK1SIGMAR1POLBDRD4 | |
| Hydrochloric Acid SCHEMBL21410212 | 0.79 | SIGMAR1 (0.76) | KMT2AMAPK1SIGMAR1POLBDRD4 | |
| SCHEMBL5501378 | 0.78 | KMT2A (0.57) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607952-A | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS, ATHEROSCLEROSIS AND ANTIDIABETIC AGENTS | SANOFI (FR) | 1997-03-04 | — | — | US | disclosed |