Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.60 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | BACE1 | P56817 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325622 | 0.87 | ALDH1A1 (0.68) | SIGMAR1ACHEBACE1KCNH2ALDH1A1 | |
| Bromide SCHEMBL8824061 | 0.85 | ALDH1A1 (0.67) | SIGMAR1ACHEBACE1KCNH2ALDH1A1 | |
| SCHEMBL14115981 | 0.85 | SIGMAR1 (0.67) | SIGMAR1ACHEBACE1KCNH2KMT2A | |
| SCHEMBL14115982 | 0.81 | SMN1; SMN2 (0.58) | SIGMAR1ACHEBACE1ALDH1A1MAPK1 | |
| SCHEMBL14116032 | 0.78 | ACHE (0.62) | SIGMAR1ACHEBACE1BCHE | |
| SCHEMBL5844682 | 0.78 | BACE1 (0.61) | SIGMAR1ACHEBACE1KCNH2ALDH1A1 | |
| SCHEMBL14116235 | 0.78 | SIGMAR1 (0.74) | SIGMAR1ACHEBACE1KCNH2 | |
| SCHEMBL14101123 | 0.78 | SIGMAR1 (0.70) | SIGMAR1ACHEBACE1KMT2ATEAD1 | |
| SCHEMBL14100464 | 0.77 | SIGMAR1 (0.64) | SIGMAR1ACHEBACE1KMT2ATEAD1 | |
| SCHEMBL12642482 | 0.77 | SIGMAR1 (0.72) | SIGMAR1ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100564-A1 | LTA4H MODULATORS AND USES THEROF | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |
| EP-1660492-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-20 | — | — | EP | disclosed |