Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8824061 | 0.98 | ALDH1A1 (0.67) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL5844682 | 0.91 | BACE1 (0.61) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL19743237 | 0.87 | KCNH2 (0.60) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL14100444 | 0.87 | SIGMAR1 (0.60) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL27780880 | 0.85 | SIGMAR1 (0.67) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL5230894 | 0.85 | SIGMAR1 (0.74) | KMT2AMAPK1KCNH2SIGMAR1POLB | |
| SCHEMBL4202978 | 0.85 | SIGMAR1 (0.65) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 | |
| SCHEMBL2425554 | 0.81 | SIGMAR1 (0.78) | KMT2AMAPK1SIGMAR1POLBDRD4 | |
| Hydrochloric Acid SCHEMBL21410212 | 0.80 | SIGMAR1 (0.76) | KMT2AMAPK1SIGMAR1POLBDRD4 | |
| SCHEMBL5501378 | 0.80 | KMT2A (0.57) | ALDH1A1KMT2AMAPK1KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353089-B2 | Compositions and methods for the treatment of malaria | SAINT LOUIS UNIVERSITY (US) | 2016-05-31 | — | — | US | disclosed |
| WO-2015028989-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS ANTIMALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-03-05 | — | — | WO | disclosed |
| US-8933101-B2 | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-13 | — | — | US | disclosed |
| WO-2014160775-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA | SAINT LOUIS UNIVERSITY (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20140296532-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2014-10-02 | — | — | US | disclosed |
| US-20100120860-A1 | THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN-CILAG S.A., (ES) | 2010-05-13 | — | — | US | disclosed |
| EP-2148879-A1 | THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008128996-A1 | THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-30 | — | — | WO | disclosed |
| EP-0719775-B1 | Substituted 4-phenyl thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 2000-07-12 | — | — | EP | disclosed |
| WO-2000024740-A1 | METHOD FOR PREPARING 4-(2-AMINO-1,3-THIAZOL-4-YL) BENZENECARBOXIMIDAMIDE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2000-05-04 | — | — | WO | disclosed |
| EP-0981518-A1 | SUBSTITUTED HETEROCYCLIC NITROGENS, METHODS FOR PRODUCING SAME AND THEIR USE AS PEST CONTROL AGENT | Hoechst Schering AgrEvo GmbH (DE) | 2000-03-01 | — | — | EP | disclosed |
| WO-1998051674-A1 | SUBSTITUTED HETEROCYCLIC NITROGENS, METHODS FOR PRODUCING SAME AND THEIR USE AS PEST CONTROL AGENT | HOECHST SCHERING AGREVO GMBH (DE) | 1998-11-19 | — | — | WO | disclosed |
| EP-0719775-A1 | Substituted 4-phenyl thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-07-03 | — | — | EP | disclosed |
| EP-0206415-B1 | (4-PIPERIDINYLMETHYL AND -HETERO)PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-01-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296532-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA | BACE2, DNPEP, ACE | ALDH1A1 1822/4885KMT2A 960/4885MAPK1 4778/4885 |
| US-20100120860-A1 | THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | GRIN2A, DRD2, GRIN2C | ALDH1A1 735/4885KMT2A 971/4885MAPK1 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.