Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278422 | 0.89 | CA12 (0.56) | OPRD1OPRK1CA12CA1CA2 | |
| SCHEMBL28239943 | 0.88 | HRH2 (0.43) | OPRD1OPRK1CA12CA1CA2 | |
| SCHEMBL16639869 | 0.81 | OPRM1 (0.56) | OPRD1OPRK1CA12CA1CA2 | |
| SCHEMBL1447090 | 0.81 | OPRD1 (0.56) | OPRD1OPRK1OPRM1APPLMNA | |
| SCHEMBL5592248 | 0.81 | OPRD1 (0.55) | OPRD1OPRK1OPRM1APPLMNA | |
| SCHEMBL4064856 | 0.80 | OPRD1 (0.46) | OPRD1OPRK1HRH3OPRM1APP | |
| SCHEMBL8824371 | 0.80 | OPRD1 (0.54) | OPRD1OPRK1OPRM1APPLMNA | |
| SCHEMBL16244835 | 0.80 | OPRD1 (0.57) | OPRD1OPRK1OPRM1APPLMNA | |
| SCHEMBL3455760 | 0.80 | CA12 (0.51) | OPRD1CA12CA1CA2CA9 | |
| SCHEMBL27472889 | 0.80 | OPRD1 (0.57) | OPRD1OPRK1OPRM1APPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663352-A | 4-phenyl-4-phenylpropyl(enyl)-piperidines as tachykinin antagonists | MERCK SHARP & DOHME LIMITED (GB) | 1997-09-02 | — | — | US | disclosed |
| US-5661162-A | 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperdines as tachykinin receptor antagonists | MERCK SHARP & DOHME LIMITED (GB) | 1997-08-26 | — | — | US | disclosed |
| EP-0711281-A1 | 4-PHENYL-4-PHENYLPROPYL(ENYL)-PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-05-15 | — | — | EP | disclosed |
| EP-0673367-A1 | 4-AMINOMETHYL/THIOMETHYL/SULFONYLMETHYL-4-PHENYLPIPERIDINES AS TACHYKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1995-09-27 | — | — | EP | disclosed |
| WO-1995004042-A1 | 4-PHENYL-4-PHENYLPROPYL(ENYL)-PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |
| WO-1994013639-A1 | 4-AMINOMETHYL/THIOMETHYL/SULFONYLMETHYL-4-PHENYLPIPERIDINES AS TACHYKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-06-23 | — | — | WO | disclosed |