Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 5/20 | 0.40 |
| ▸ | HRH1 | P35367 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3555626 | 0.81 | POLB (0.48) | OPRD1OPRK1POLBGRM5 | |
| SCHEMBL8824367 | 0.80 | OPRD1 (0.53) | OPRD1OPRK1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL3567709 | 0.80 | F11 (0.41) | OPRD1HRH3ALDH1A1KMT2A | |
| SCHEMBL28239943 | 0.76 | HRH2 (0.43) | OPRD1OPRK1HRH2HRH1LMNA | |
| SCHEMBL12520220 | 0.76 | OPRD1 (0.42) | OPRD1OPRK1HRH2HRH1LMNA | |
| SCHEMBL30237100 | 0.76 | OPRD1 (0.43) | OPRD1OPRK1HRH2HRH1LMNA | |
| SCHEMBL30237267 | 0.74 | OPRK1 (0.48) | OPRD1OPRK1HRH2HRH1LMNA | |
| SCHEMBL27396277 | 0.74 | OPRD1 (0.51) | OPRD1OPRK1HRH2HRH1LMNA | |
| SCHEMBL6247236 | 0.74 | APP (0.59) | LMNASMN1; SMN2APPALDH1A1MAPT | |
| SCHEMBL22631375 | 0.73 | KRAS (0.43) | OPRD1OPRK1HRH2HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729772-A4 | HETEROARYL PIPERIDINE GLYCINE TRANSPORTER INHIBITORS | MERCK & CO INC (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1729772-A2 | HETEROARYL PIPERIDINE GLYCINE TRANSPORTER INHIBITORS | Merck and Co., Inc. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005094514-A2 | HETEROARYL PIPERIDINE GLYCINE TRANSPORTER INHIBITORS | MERCK & CO., INC. (US) | 2005-10-13 | — | — | WO | disclosed |