Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.45 |
| ▸ | PPARA | Q07869 | 7/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825152 | 1.00 | PPARG (0.45) | PPARGPPARALTB4RSMPD1THRA | |
| SCHEMBL8825445 | 0.83 | LTB4R (0.60) | LTB4R | |
| SCHEMBL8825437 | 0.83 | LTB4R (0.60) | LTB4R | |
| SCHEMBL8825418 | 0.78 | PPARG (0.41) | PPARGPPARALTB4RSMPD1THRA | |
| SCHEMBL8825101 | 0.73 | MAPT (0.39) | PPARGPPARALTB4R | |
| SCHEMBL24950547 | 0.67 | SMPD1 (0.67) | SMPD1THRATHRB | |
| SCHEMBL9565566 | 0.67 | SMPD1 (0.67) | SMPD1THRATHRB | |
| SCHEMBL967401 | 0.67 | SMPD1 (0.67) | SMPD1THRATHRB | |
| SCHEMBL9304902 | 0.67 | SMPD1 (0.67) | SMPD1THRATHRB | |
| SCHEMBL9445376 | 0.66 | PLA2G2D (0.50) | LTB4RSMPD1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |