Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825101 | 0.96 | MAPT (0.39) | PPARGPPARALTB4RALDH1A1HPGD | |
| SCHEMBL8825493 | 0.84 | PPARG (0.54) | PPARGPPARA | |
| SCHEMBL8825282 | 0.83 | LTB4R (0.54) | LTB4RALDH1A1HPGD | |
| SCHEMBL8825460 | 0.83 | PPARG (0.43) | PPARGPPARALTB4R | |
| SCHEMBL8825193 | 0.82 | LTB4R (0.45) | PPARGPPARALTB4RNPC1PRKCA | |
| SCHEMBL8825269 | 0.80 | PTPN11 (0.41) | ALDH1A1HPGD | |
| SCHEMBL8825203 | 0.80 | ALOX15 (0.36) | — | |
| SCHEMBL8825152 | 0.78 | PPARG (0.45) | PPARGPPARALTB4RSMPD1THRA | |
| SCHEMBL8825147 | 0.78 | PPARG (0.45) | PPARGPPARALTB4RSMPD1THRA | |
| SCHEMBL8825480 | 0.77 | LTB4R (0.46) | LTB4RALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |
| EP-0651745-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002464-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-03 | — | — | WO | disclosed |