Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 5/20 | 0.60 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 3/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825437 | 1.00 | LTB4R (0.60) | LTB4RPTPN11TP53TSHRPLA2G4B | |
| SCHEMBL8825147 | 0.83 | PPARG (0.45) | LTB4R | |
| SCHEMBL8825282 | 0.77 | LTB4R (0.54) | LTB4RPTPN11TP53TSHRPLA2G4B | |
| SCHEMBL9493086 | 0.75 | LTB4R (1.00) | LTB4RPTPN11 | |
| SCHEMBL8825480 | 0.70 | LTB4R (0.46) | LTB4RTP53TSHRPLA2G4BALDH1A1 | |
| SCHEMBL9491693 | 0.70 | LTB4R (0.60) | LTB4RPTPN11 | |
| SCHEMBL9445352 | 0.69 | LTB4R (0.70) | LTB4RPTPN11CYSLTR2CYSLTR1 | |
| SCHEMBL9493089 | 0.69 | LTB4R (0.59) | LTB4RPTPN11ALDH1A1CYSLTR2CYSLTR1 | |
| SCHEMBL9445193 | 0.68 | PLA2G2D (0.58) | LTB4RPTPN11TP53TSHRPLA2G4B | |
| SCHEMBL1200986 | 0.67 | ALDH1A1 (0.69) | PTPN11TP53TSHRPLA2G4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |