Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8827501 | 0.78 | HCAR3 (0.39) | MAPTCYP3A4CYP2D6CYP2C9EGFR | |
| SCHEMBL8827458 | 0.76 | KMT2A (0.44) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL8827512 | 0.76 | MAPT (0.45) | SMN1; SMN2HPGDALDH1A1POLBMEN1 | |
| SCHEMBL5743821 | 0.75 | GSK3B (0.56) | SMN1; SMN2HPGDALDH1A1POLBMEN1 | |
| SCHEMBL7262125 | 0.73 | MAPT (0.61) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL20445842 | 0.71 | IDO1 (0.50) | ALDH1A1POLBMEN1KMT2AMAPT | |
| SCHEMBL27456953 | 0.71 | CYP1A2 (0.42) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL7262122 | 0.70 | MAPT (0.41) | ALDH1A1POLBMEN1KMT2AMAPT | |
| SCHEMBL11150396 | 0.70 | TXNRD1 (0.49) | SMN1; SMN2HPGDALDH1A1POLBMEN1 | |
| SCHEMBL3204572 | 0.68 | CYP1A2 (0.68) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698560-A | TREATMENT OF CARDIOVASCULAR DISORDERS; ANTICOAGULANTS; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS; ARTERIOSCLEROSIS; CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-12-16 | — | — | US | disclosed |