Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | F2R | P25116 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637836 | 0.87 | HDAC3 (0.65) | KCNK3HTTLMNAMEN1KMT2A | |
| SCHEMBL10069466 | 0.84 | F2R (0.82) | KCNK3HTTF2RMEN1KMT2A | |
| SCHEMBL17354443 | 0.84 | KMT2A (0.78) | HTTF2RMEN1KMT2ATSHR | |
| SCHEMBL8278813 | 0.82 | LMNA (0.78) | LMNASMN1; SMN2 | |
| SCHEMBL24933360 | 0.82 | RAB9A (0.73) | KCNK3HTTLMNAMEN1KMT2A | |
| SCHEMBL10975643 | 0.80 | F2R (0.73) | F2RRAB9A | |
| SCHEMBL259177 | 0.80 | TDP1 (0.78) | KCNK3HTTLMNAMEN1KMT2A | |
| SCHEMBL25155011 | 0.79 | LMNA (1.00) | LMNAMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL3634265 | 0.79 | RAB9A (0.69) | LMNAKMT2ASMN1; SMN2HIF1ARAB9A | |
| SCHEMBL874202 | 0.79 | F2R (0.70) | KCNK3HTTF2RMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |