Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | VCP | P55072 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828230 | 1.00 | HSD17B10 (0.60) | HSD17B10CYP1A2HDAC6HDAC3HDAC1 | |
| SCHEMBL20702283 | 0.82 | ALDH1A1 (0.53) | HSD17B10CYP1A2HDAC6HDAC3HDAC1 | |
| SCHEMBL14552385 | 0.81 | SOAT1 (0.56) | HSD17B10CYP1A2HDAC6HDAC3HDAC1 | |
| SCHEMBL2453908 | 0.80 | CYP3A4 (0.61) | HSD17B10CYP1A2HDAC6HDAC3HDAC1 | |
| SCHEMBL2005021 | 0.80 | CYP3A4 (0.61) | HSD17B10CYP1A2HDAC6HDAC3HDAC1 | |
| SCHEMBL15517799 | 0.79 | MAOA (0.60) | HSD17B10CYP1A2HDAC6HDAC3HDAC1 | |
| SCHEMBL15509220 | 0.79 | MAOA (0.60) | HSD17B10CYP1A2HDAC6HDAC3HDAC1 | |
| SCHEMBL4745288 | 0.79 | KDM4E (0.81) | HSD17B10CYP1A2HDAC6ALDH1A1KDM4E | |
| SCHEMBL79427 | 0.79 | KDM4E (0.81) | HSD17B10CYP1A2HDAC6ALDH1A1KDM4E | |
| SCHEMBL1254171 | 0.79 | ALDH1A1 (0.62) | HSD17B10CYP1A2HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| US-5047417-A | Butenoic or propenoic acid derivatives | EISAI CO. LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |