Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005021 | 1.00 | CYP3A4 (0.61) | CYP3A4ATMCYP19A1ALDH1A1HSD17B10 | |
| SCHEMBL11480398 | 0.89 | KDM4E (0.58) | CYP3A4ATMCYP19A1ALDH1A1HDAC6 | |
| SCHEMBL11480395 | 0.89 | KDM4E (0.58) | CYP3A4ATMCYP19A1ALDH1A1HDAC6 | |
| SCHEMBL19472000 | 0.82 | CYP19A1 (0.78) | CYP3A4ATMCYP19A1ALDH1A1HSD17B10 | |
| SCHEMBL19500874 | 0.82 | CYP19A1 (0.78) | CYP3A4ATMCYP19A1ALDH1A1HSD17B10 | |
| SCHEMBL8152968 | 0.82 | CYP3A4 (0.61) | CYP3A4ATMCYP19A1ALDH1A1HSD17B10 | |
| SCHEMBL2771009 | 0.82 | CYP3A4 (0.61) | CYP3A4ATMCYP19A1ALDH1A1HSD17B10 | |
| SCHEMBL22187024 | 0.82 | CYP3A4 (0.61) | CYP3A4ATMCYP19A1ALDH1A1HSD17B10 | |
| SCHEMBL256709 | 0.82 | CYP3A4 (0.66) | CYP3A4ATMCYP19A1ALDH1A1HSD17B10 | |
| SCHEMBL10421648 | 0.82 | CYP19A1 (0.62) | CYP3A4ATMCYP19A1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58041874-A | — | — | None | — | — | JP | disclosed |
| US-20260028340-A1 | SUBSTITUTED DERIVATIVES OF ISOINDOLES | SUPERNUS PHARMACEUTICALS, INC. (US) | 2026-01-29 | — | — | US | disclosed |
| US-12454535-B2 | Substituted derivatives of isoindoles | SUPERNUS PHARMACEUTICALS, INC. (US) | 2025-10-28 | — | — | US | disclosed |
| US-20250197412-A1 | SUBSTITUTED DERIVATIVES OF ISOINDOLES | SUPERNUS PHARMACEUTICALS, INC. (US) | 2025-06-19 | — | — | US | disclosed |
| US-8017646-B2 | e.g. 1-{3-[3-(3,4-dimethoxyphenyl)propoxy]propyl}pyrrolidine; neurodegenerative disorders, antidepressant, antidiabetic, hypotensive agent, cognition activator; | BIOPROJET (FR) | 2011-09-13 | — | — | US | disclosed |
| US-20080182876-A1 | Histamine H3-Receptor Ligands and Their Therapeutic Application | BIOPROJET (FR) | 2008-07-31 | — | — | US | disclosed |
| EP-1874747-A1 | HISTAMINE H3-RECEPT0R LIGANDS AND THEIR THERAPEUTIC APPLICATION | BIOPROJET (FR) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006117611-A1 | HISTAMINE H3-RECEPT0R LIGANDS AND THEIR THERAPEUTIC APPLICATION | BIOPROJET (FR) | 2006-11-09 | — | — | WO | disclosed |
| EP-1717233-A1 | Histamine H3-receptor ligands and their therapeutic application | BIOPROJET (FR) | 2006-11-02 | — | — | EP | disclosed |
| US-6025310-A | RETAINING STABILITY FREE OF HYDROLYSIS FOR PROLONGED PERIOD OF TIME, COMPATIBLE WITH ORGANIC LUBRICANTS HAVING BENZENE RING AND PHOSPHAZINE RING | KUBOTA CORPORATION (JP) | 2000-02-15 | — | — | US | disclosed |
| JP-S5841874-A | PRODUCTION OF LIGNAN | TSUMURA JUNTENDO INC | 1983-03-11 | — | — | JP | disclosed |
| US-4052993-A | CINNAMIC DERIVATIVES AS TOBACCO ADDITIVES | LIGGETT & MYERS INCORPORATED (US) | 1977-10-11 | — | — | US | disclosed |
| US-3943943-A | Cinnamic derivatives as tobacco additives | LIGGETT & MYERS INCORPORATED (US) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260028340-A1 | SUBSTITUTED DERIVATIVES OF ISOINDOLES | ADRB3, ADRB2, SLC6A3 | CYP3A4 366/4885ATM 1554/4885CYP19A1 1155/4885 |
| US-12454535-B2 | Substituted derivatives of isoindoles | TPH2, CYP11B2, CYP3A5 | CYP3A4 33/4885ATM 2126/4885CYP19A1 557/4885 |
| US-20250197412-A1 | SUBSTITUTED DERIVATIVES OF ISOINDOLES | OPRK1, TPH2, NLN | CYP3A4 297/4885ATM 1648/4885CYP19A1 1289/4885 |
| US-20080182876-A1 | Histamine H3-Receptor Ligands and Their Therapeutic Application | HRH3, HRH4, HRH1 | CYP3A4 1277/4885ATM 3227/4885CYP19A1 2075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.