Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.57 |
| ▸ | HTR3A | P46098 | 3/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.56 |
| ▸ | HTR3B | O95264 | 2/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17658996 | 0.83 | HTR1A (0.72) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL8226269 | 0.82 | HTR1A (0.59) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL7240022 | 0.82 | SLC6A2 (0.55) | HTR1ASLC6A2SLC6A4CYP2C19SIGMAR1 | |
| Hydrochloric Acid SCHEMBL23783250 | 0.81 | SLC6A2 (0.58) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| Hydrochloric Acid SCHEMBL30032096 | 0.81 | SLC6A2 (0.58) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL30747759 | 0.81 | HTR3A (0.71) | HTR1AHTR6HTR3AHTR3EHTR3B | |
| SCHEMBL233151 | 0.81 | HTR3A (0.71) | HTR1AHTR6HTR3AHTR3EHTR3B | |
| SCHEMBL8257048 | 0.81 | HTR3A (0.52) | HTR1ASLC6A2SLC6A4HTR6HTR3A | |
| Hydrochloric Acid SCHEMBL4905371 | 0.80 | HTR3A (0.69) | HTR1AHTR6HTR3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL7711668 | 0.80 | HTR3A (0.69) | HTR1AHTR6HTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688795-A | URINARY TRACTS OBSTRUCTION | SYNTEX (U.S.A.) INC. (US) | 1997-11-18 | — | — | US | disclosed |
| CN-1136039-A | [3- (4-phenylpiperazin-1-yl) propylamino, thio and oxy ] -pyridine, pyrimidine and benzene derivatives | HOFFMANN LA ROCHE (CH) | 1996-11-20 | — | — | CN | disclosed |
| EP-0711757-A1 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy -pyridine, pyrimidine and benzene derivatives as alpha1-adrenoceptor antagonists | F. Hoffmann-La Roche AG (CH) | 1996-05-15 | — | — | EP | disclosed |