Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828753 | 0.82 | ADRA1D (0.58) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL8828767 | 0.82 | ADRA1D (0.73) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9027560 | 0.81 | ADRA1D (0.72) | ADRA1DADRA1AADRA1B | |
| SCHEMBL8828464 | 0.81 | DRD2 (0.57) | DRD2HTR2A | |
| SCHEMBL9760092 | 0.75 | HTR1A (0.62) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL8828771 | 0.75 | DRD2 (0.54) | DRD2HTR7 | |
| SCHEMBL9760272 | 0.75 | DRD2 (0.67) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9027734 | 0.74 | ADRA1D (0.75) | ADRA1DADRA1AADRA1B | |
| SCHEMBL9760177 | 0.74 | HTR1A (0.73) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9027618 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688795-A | URINARY TRACTS OBSTRUCTION | SYNTEX (U.S.A.) INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0711757-A1 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy -pyridine, pyrimidine and benzene derivatives as alpha1-adrenoceptor antagonists | F. Hoffmann-La Roche AG (CH) | 1996-05-15 | — | — | EP | disclosed |