Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8829288 | 0.90 | NOS2 (0.37) | NOS2NOS3 | |
| SCHEMBL8829298 | 0.86 | NOS2 (0.39) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL9596752 | 0.72 | AGTR2 (0.41) | — | |
| SCHEMBL8829283 | 0.70 | GRM5 (0.32) | — | |
| SCHEMBL26177037 | 0.62 | NOS2 (0.66) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL9019314 | 0.62 | NOS2 (0.50) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL8829129 | 0.61 | L3MBTL1 (0.36) | — | |
| SCHEMBL5601012 | 0.61 | KCNH2 (0.33) | NOS2 | |
| SCHEMBL23987750 | 0.59 | NOS2 (0.61) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL21567686 | 0.59 | NOS2 (0.56) | NOS2NOS3CCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661158-A | HYPOTENSIVE AGENTS, ANTICHOLESTEROL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| EP-0655915-A1 | USE OF ANGIOTENSIN II ANTAGONISTS FOR THE TREATMENT OF HYPERLIPIDAEME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004153-A1 | USE OF ANGIOTENSIN II ANTAGONISTS FOR THE TREATMENT OF HYPERLIPIDAEME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-03 | — | — | WO | disclosed |
| US-5215994-A | Treating or preventing hypertension or heart failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | disclosed |
| US-5210092-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0480204-A1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |