SCHEMBL8829657

SCHEMBL8829657

CCc1cn(-c2cccc(OC(F)(F)F)c2)c(=N)s1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RXRA P19793 10/20 0.42
GRIN1 Q05586 10/20 0.42
GRIN2B Q13224 10/20 0.42
KCNH2 Q12809 3/20 0.40
PDE10A Q9Y233 1/20 0.36
PIM1 P11309 1/20 0.36
FLT1 P17948 1/20 0.36
KDR P35968 1/20 0.36
MLYCD O95822 1/20 0.35
FFAR4 Q5NUL3 1/20 0.35
NOTUM Q6P988 1/20 0.34
CCKAR P32238 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8425506 0.83 RXRA (0.39) RXRAGRIN1GRIN2BKCNH2PDE10A
SCHEMBL8010810 0.82 HTT (0.41) RXRAGRIN1GRIN2BNOTUM
SCHEMBL8829702 0.73 AR (0.40) RXRAGRIN1GRIN2B
SCHEMBL7154140 0.68 KCNH2 (0.47) RXRAGRIN1GRIN2BKCNH2PDE10A
SCHEMBL178310 0.67 CHRM2 (0.55) GRIN2B
SCHEMBL4231575 0.67 POLB (0.40) RXRAGRIN1GRIN2B
SCHEMBL8425380 0.67 RXRA (0.39) RXRAGRIN1GRIN2B
SCHEMBL8139457 0.66 KCNH2 (0.43) RXRAGRIN1GRIN2BKCNH2PDE10A
SCHEMBL21863291 0.66 RXRA (0.73) RXRAGRIN1GRIN2BKCNH2NOTUM
Hydrochloric Acid SCHEMBL21272596 0.65 CHRM2 (0.52) GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5463069-A Process of producing 2-iminothiazoline derivatives and process of producing their intermediates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-10-31 US claimed
CN-1125045-C Process for producing intermecliates used in process for producing-2-iminothiazoline derivatives SUMITOMO CHEMICAL CO (JP) 2003-10-22 CN disclosed
CN-1073099-C Process for producing intermecliates used in process for producing 2-iminothiazoline derivatives SUMITOMO CHEMICAL CO (JP) 2001-10-17 CN disclosed
CN-1228420-A Process for producing intermecliates used in process for producing-2-iminothiazoline derivatives SUMITOMO CHEMICAL CO (JP) 1999-09-15 CN disclosed
CN-1225363-A Process for producing intermediate in process for producing 2-iminothiazoline derivative SUMITOMO CHEMICAL CO (JP) 1999-08-11 CN disclosed
CN-1042224-C Process for preparing 2-iminothiazoline derivatives SUMITOMO CHEMICAL CO (JP) 1999-02-24 CN disclosed
US-5684196-A N-SUBSTITUTED-N-ARYLCYANAMIDE SUMITOMO CHEMICAL CO., LTD. (JP) 1997-11-04 US disclosed
US-5648533-A Process of producing 2-iminothiazoline derivatives and process of producing their intermediates SUMITOMO CHEMICAL CO., LTD. (JP) 1997-07-15 US disclosed
EP-0600489-B1 Process for producing 2-iminothiazoline derivatives and process for producing their intermediates SUMITOMO CHEMICAL CO (JP) 1996-11-06 EP disclosed
US-5463069-A Process of producing 2-iminothiazoline derivatives and process of producing their intermediates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-10-31 US disclosed
CN-1097007-A Process for preparing 2-iminothiazoline derivatives and process for preparing intermediates thereof SUMITOMO CHEMICAL CO (JP) 1995-01-04 CN disclosed
EP-0600489-A1 Process for producing 2-iminothiazoline derivatives and process for producing their intermediates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-06-08 EP disclosed