Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | RXRA | P19793 | 10/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7155477 | 0.83 | KCNH2 (0.42) | KCNH2RXRAGRIN1GRIN2BPIM1 | |
| SCHEMBL7249466 | 0.83 | ALDH1A1 (0.46) | KCNH2DHFRNOTUM | |
| SCHEMBL28266413 | 0.69 | PIM1 (0.46) | KCNH2RXRAGRIN1GRIN2BPIM1 | |
| SCHEMBL178310 | 0.69 | CHRM2 (0.55) | GRIN2B | |
| SCHEMBL28266377 | 0.69 | RXRA (0.47) | KCNH2RXRAGRIN1GRIN2BPIM1 | |
| SCHEMBL7163341 | 0.69 | MAPT (0.37) | KCNH2 | |
| SCHEMBL8829657 | 0.68 | RXRA (0.42) | KCNH2RXRAGRIN1GRIN2BPIM1 | |
| SCHEMBL8139457 | 0.68 | KCNH2 (0.43) | KCNH2RXRAGRIN1GRIN2BPDE10A | |
| SCHEMBL21863291 | 0.68 | RXRA (0.73) | KCNH2RXRAGRIN1GRIN2BNOTUM | |
| Hydrochloric Acid SCHEMBL21272596 | 0.66 | CHRM2 (0.52) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002060877-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | WO | disclosed |