SCHEMBL8832034

SCHEMBL8832034

BrCC1c2ccccc2-c2ccccc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.58
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
GPR3 P46089 2/20 0.41
TDO2 P48775 1/20 0.38
ACHE P22303 2/20 0.38
CHRM2 P08172 1/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
CHRM1 P11229 1/20 0.38
DRD1 P21728 1/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
ADRA1A P35348 1/20 0.38
OPRM1 P35372 1/20 0.38
DRD3 P35462 1/20 0.38
SLC6A3 Q01959 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
SLC22A2 O15244 1/20 0.36
SLC22A3 O75751 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5792714 0.84 ALDH1A1 (0.45) HTR2ACA1CA2TDO2BCHE
SCHEMBL29617353 0.80 HTR2A (0.54) HTR2ACA1CA2GPR3TDO2
SCHEMBL5355395 0.80 HTR2A (0.54) HTR2ACA1CA2GPR3TDO2
SCHEMBL31026220 0.78 HTR2A (0.52) HTR2ACA1CA2GPR3TDO2
SCHEMBL14759063 0.78 HTR2A (0.52) HTR2ACA1CA2GPR3TDO2
SCHEMBL8715922 0.78 HTR2A (0.42) HTR2ACA1CA2GPR3TDO2
SCHEMBL7576966 0.78 HTR2A (0.64) HTR2ACA1CA2GPR3TDO2
SCHEMBL5353138 0.78 HTR2A (0.64) HTR2ACA1CA2GPR3TDO2
SCHEMBL5820544 0.77 HTR2A (0.50) HTR2ACA1CA2GPR3TDO2
SCHEMBL7574105 0.76 HTR2A (0.61) HTR2ACA1CA2GPR3TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578741-A OLEFIN POLYMERIZATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1996-11-26 US claimed
WO-1997048705-A1 POTASSIUM CHANNEL BLOCKERS UNIVERSITY COLLEGE LONDON (GB) 1997-12-24 WO disclosed
US-5650528-A Metallocene compounds PHILLIPS PETROLEUM COMPANY (US) 1997-07-22 US disclosed
US-5646323-A COMPLEXING CYCLOPENTADIENYL-TYPE LIGAND, ALKALI METAL ALKYL, AND GROUP IVB OR VB METAL HALIDE TO FORM POLYMERIZATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1997-07-08 US disclosed
US-5591879-A INTERMEDIATES FOR METALLOCENE POLYMERIZATION CATALYSTS PHILLIPS PETROLEUM COMPANY (US) 1997-01-07 US disclosed
US-5583189-A USING A CATALYST SYSTEM COMPRISING THE REACTION PRODUCT OF A METALLOCENE COMPOUND, A SOLID ORGANOALUMINOXY PRODUCT AND AN ORGANOMETAL COMPOUND PHILLIPS PETROLEUM COMPANY (US) 1996-12-10 US disclosed
US-5578741-A OLEFIN POLYMERIZATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1996-11-26 US disclosed
US-5565396-A METALLOCENE AND AN ORGANOALUMINOXANE COCATALYST FOR HOMO OR COPOLYMERIZING OLEFINS PHILLIPS PETROLEUM COMPANY (US) 1996-10-15 US disclosed
US-5563284-A COORDINATION CATALYSTS PHILLIPS PETROLEUM COMPANY (US) 1996-10-08 US disclosed
US-5554795-A Process for preparing cyclopentadienyl-type ligands PHILLIPS PETROLEUM COMPANY (US) 1996-09-10 US disclosed
US-5496781-A OLEFIN POLYMERIZATION PHILLIPS PETROLEUM COMPANY (US) 1996-03-05 US disclosed
EP-0683179-A1 Metallocene catalyst systems, preparation, and use PHILLIPS PETROLEUM COMPANY (US) 1995-11-22 EP disclosed
EP-0049628-B1 NONAPEPTIDE AND DECAPEPTIDE ANALOGS OF LHRH, USEFUL AS LHRH ANTAGONISTS, METHODS OF MAKING THEM, AND THEIR PHARMACEUTICAL USES SYNTEX (U.S.A.) INC. (US) 1985-07-03 EP disclosed
EP-0021234-B1 NONAPEPTIDE AND DECAPEPTIDE DERIVATIVES OF LUTEINIZING HORMONE RELEASING HORMONE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SYNTEX (U.S.A.) INC. (US) 1984-08-22 EP disclosed
US-4419347-A Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists SYNTEX (U.S.A.) INC. (US) 1983-12-06 US disclosed
US-4341767-A Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists SYNTEX INC. (US) 1982-07-27 US disclosed
EP-0049628-A2 Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists, methods of making them, and their pharmaceutical uses SYNTEX (U.S.A.) INC. (US) 1982-04-14 EP disclosed
EP-0021234-A1 Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone, their preparation and pharmaceutical compositions containing them SYNTEX (U.S.A.) INC. (US) 1981-01-07 EP disclosed
US-4234571-A CONTRACEPTIVES, ANTIFERTILITY AGENTS SYNTEX (U.S.A.) INC. (US) 1980-11-18 US disclosed