Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8831988 | 0.83 | KDM4E (0.33) | MEN1ALDH1A1KMT2AHTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL8831930 | 0.77 | MC4R (0.39) | SIGMAR1MEN1ALDH1A1KMT2AADRA2A | |
| Hydrochloric Acid SCHEMBL8852413 | 0.73 | HTR2A (0.43) | ADRA2AADRA2BHTR2AHRH1KCNH2 | |
| Hydrochloric Acid SCHEMBL8831536 | 0.71 | — | — | |
| SCHEMBL8851929 | 0.69 | OPRD1 (0.37) | KCNA5SIGMAR1MEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL8831810 | 0.68 | KCNA5 (0.32) | KCNA5SIGMAR1PGRADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL8831944 | 0.68 | KCNA5 (0.32) | KCNA5SIGMAR1PGRADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL8831645 | 0.68 | PGR (0.33) | KCNA5SIGMAR1ALDH1A1PGRADRA2A | |
| Hydrochloric Acid SCHEMBL6813856 | 0.67 | — | — | |
| SCHEMBL516288 | 0.65 | SIGMAR1 (0.45) | KCNA5SIGMAR1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650528-A | Metallocene compounds | PHILLIPS PETROLEUM COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5646323-A | COMPLEXING CYCLOPENTADIENYL-TYPE LIGAND, ALKALI METAL ALKYL, AND GROUP IVB OR VB METAL HALIDE TO FORM POLYMERIZATION CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-07-08 | — | — | US | disclosed |
| US-5591879-A | INTERMEDIATES FOR METALLOCENE POLYMERIZATION CATALYSTS | PHILLIPS PETROLEUM COMPANY (US) | 1997-01-07 | — | — | US | disclosed |
| US-5578741-A | OLEFIN POLYMERIZATION CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| US-5565396-A | METALLOCENE AND AN ORGANOALUMINOXANE COCATALYST FOR HOMO OR COPOLYMERIZING OLEFINS | PHILLIPS PETROLEUM COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
| US-5563284-A | COORDINATION CATALYSTS | PHILLIPS PETROLEUM COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| US-5554795-A | Process for preparing cyclopentadienyl-type ligands | PHILLIPS PETROLEUM COMPANY (US) | 1996-09-10 | — | — | US | disclosed |