Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | VNN1 | O95497 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541922 | 0.83 | ALDH1A1 (0.48) | TDP1POLBAPEX1HPGDLMNA | |
| SCHEMBL7256741 | 0.83 | TDP1 (0.55) | TDP1POLBAPEX1KDM4EGAA | |
| SCHEMBL526194 | 0.83 | GAA (0.57) | TDP1POLBAPEX1KDM4EGAA | |
| SCHEMBL6957846 | 0.82 | HPGD (0.60) | TDP1POLBAPEX1HPGDGAA | |
| SCHEMBL12731522 | 0.82 | GAA (0.48) | TDP1POLBAPEX1KDM4EVNN1 | |
| SCHEMBL5548416 | 0.82 | IAPP (0.44) | TDP1POLBAPEX1HPGDKDM4E | |
| SCHEMBL1411319 | 0.82 | L3MBTL1 (0.62) | TDP1HPGDVNN1GAALMNA | |
| SCHEMBL106914 | 0.82 | CA2 (0.54) | TDP1KDM4ELMNAHIF1ATP53 | |
| SCHEMBL6701560 | 0.80 | TDP1 (0.53) | TDP1POLBAPEX1KDM4EVNN1 | |
| SCHEMBL7256785 | 0.80 | ALDH1A1 (0.49) | TDP1POLBHPGDKDM4EVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656631-A | LIGANDS OF CHOLINERGIC RECEPTORS; TREATMENT OF MEMORY AND NERVOUS SYSTEM DISORDERS | SANOFI (FR) | 1997-08-12 | — | — | US | disclosed |
| US-5631255-A | AFFINITY FOR CHOLINERGIC RECEPTORS, TREATMENT OF COGNITIVE AND MEMORY DISORDERS, AND DEGENERATIVE SYNDROMES | SANOFI (FR) | 1997-05-20 | — | — | US | disclosed |
| US-5461053-A | Cognition activator | SANOFI (FR) | 1995-10-24 | — | — | US | disclosed |