Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 9/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.32 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215800 | 1.00 | LMNA (0.37) | LMNAEGLN3TBXAS1ALDH1A1MEN1 | |
| SCHEMBL8833195 | 0.94 | LMNA (0.40) | LMNATBXAS1ALDH1A1MEN1KMT2A | |
| SCHEMBL8832980 | 0.85 | LMNA (0.33) | LMNAEGLN3TBXAS1ALDH1A1TPSAB1 | |
| SCHEMBL9219553 | 0.85 | LMNA (0.33) | LMNAEGLN3TBXAS1ALDH1A1TPSAB1 | |
| SCHEMBL8833217 | 0.83 | ALDH1A1 (0.34) | LMNAEGLN3TBXAS1ALDH1A1 | |
| SCHEMBL8832722 | 0.81 | TBXAS1 (0.33) | LMNAEGLN3TBXAS1ALDH1A1TPSAB1 | |
| SCHEMBL9222352 | 0.81 | TBXAS1 (0.33) | LMNAEGLN3TBXAS1ALDH1A1TPSAB1 | |
| SCHEMBL8833156 | 0.80 | EGLN3 (0.35) | EGLN3MEN1KMT2A | |
| SCHEMBL9027146 | 0.79 | POLB (0.34) | KMT2A | |
| SCHEMBL9027141 | 0.79 | POLB (0.34) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5608056-A | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021186-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-28 | — | — | WO | disclosed |