Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 6/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ECE1 | P42892 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9466475 | 0.91 | LMNA (0.31) | ALDH1A1LMNAECE1 | |
| SCHEMBL9215800 | 0.83 | LMNA (0.37) | ALDH1A1LMNAEGLN3TBXAS1 | |
| SCHEMBL8833800 | 0.83 | LMNA (0.37) | ALDH1A1LMNAEGLN3TBXAS1 | |
| SCHEMBL8833409 | 0.82 | ECE1 (0.32) | SIGMAR1ECE1 | |
| SCHEMBL9543531 | 0.82 | SIGMAR1 (0.31) | SIGMAR1ECE1 | |
| SCHEMBL8833119 | 0.81 | SIGMAR1 (0.31) | SIGMAR1ECE1 | |
| SCHEMBL9213848 | 0.80 | TBXAS1 (0.40) | ALDH1A1LMNATBXAS1ECE1 | |
| SCHEMBL8833657 | 0.80 | TBXAS1 (0.40) | ALDH1A1LMNATBXAS1ECE1 | |
| SCHEMBL8832537 | 0.80 | ECE1 (0.31) | SIGMAR1ECE1 | |
| SCHEMBL8832980 | 0.80 | LMNA (0.33) | ALDH1A1LMNAEGLN3TBXAS1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5608056-A | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021186-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-28 | — | — | WO | disclosed |