Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | TDO2 | P48775 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834423 | 0.90 | MAPT (0.57) | AKR1C3AKR1C2MEN1KMT2ABRAF | |
| SCHEMBL8834430 | 0.89 | KDM4E (0.50) | AKR1C3AKR1C2MEN1KMT2ABRAF | |
| SCHEMBL5841124 | 0.81 | BRAF (0.69) | MEN1KMT2ABRAFATMGAK | |
| SCHEMBL8833788 | 0.81 | MAPT (0.67) | AKR1C3AKR1C2MEN1KMT2AKDM4E | |
| SCHEMBL8834506 | 0.80 | AKR1C3 (0.67) | AKR1C3AKR1C2MEN1KMT2AKDM4E | |
| SCHEMBL20745310 | 0.79 | KDM4E (0.71) | AKR1C3AKR1C2MEN1KMT2AKDM4E | |
| SCHEMBL12072039 | 0.78 | PTK2 (0.73) | KDM4EMAPK9MAPK10HTTALDH1A1 | |
| SCHEMBL11644754 | 0.78 | AKR1C3 (0.68) | AKR1C3AKR1C2KMT2AKDM4EALDH1A1 | |
| SCHEMBL27972004 | 0.78 | CTSV (0.58) | AKR1C3AKR1C2MEN1KMT2ABRAF | |
| SCHEMBL8833806 | 0.78 | EGFR (0.69) | MEN1KMT2ABRAFIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663336-A | IMIDATION OF DIAMINOPHTHALIC ACID TO FORM KINASE INHIBITORS AS ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5491144-A | KINASE INHIBITORS, ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-02-13 | — | — | US | disclosed |