Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8835094 | 0.83 | GRM2 (0.41) | SMN1; SMN2BACE1METRAB9ANPC1 | |
| SCHEMBL8835043 | 0.82 | NR4A2 (0.47) | SMN1; SMN2BACE1MAPTNPSR1DPP4 | |
| Ammonia Solution, Strong SCHEMBL4775543 | 0.82 | GRM2 (0.41) | SMN1; SMN2BACE1METRAB9ANPC1 | |
| Ammonia Solution, Strong SCHEMBL2248185 | 0.81 | NR4A2 (0.46) | SMN1; SMN2BACE1MAPTNPSR1DPP4 | |
| SCHEMBL9164616 | 0.81 | ATM (0.40) | SMN1; SMN2METRAB9ANPC1SCN4A | |
| SCHEMBL9162855 | 0.80 | HTR5A (0.41) | SMN1; SMN2ALOX5APFEN1 | |
| SCHEMBL9163209 | 0.80 | MAPT (0.37) | SMN1; SMN2METRAB9ANPC1MAPT | |
| SCHEMBL8835425 | 0.80 | MAPT (0.40) | SMN1; SMN2BACE1METRAB9ANPC1 | |
| Ammonia Solution, Strong SCHEMBL2248963 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2BACE1MAPTTNFDPP4 | |
| SCHEMBL9159755 | 0.79 | NCF1 (0.42) | RAB9AMAPTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5596001-A | 4-aryl-3-(heteroarylureido)quinoline derivatves | PFIZER INC. (US) | 1997-01-21 | — | — | US | disclosed |
| CN-1028754-C | process for preparing quinoline derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-07 | — | — | CN | disclosed |
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| EP-0590094-A1 | 4-ARYL-3-(HETEROARYLUREIDO)QUINOLINE DERIVATIVES | PFIZER INC. (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |
| WO-1992019614-A1 | 4-ARYL-3-(HETEROARYLUREIDO)QUINOLINE DERIVATIVES | PFIZER INC. (US) | 1992-11-12 | — | — | WO | disclosed |
| CN-1066068-A | 4-aryl-3-(fragrant heterocyclic radical urea groups) quinoline derivatives | PFIZER (US) | 1992-11-11 | — | — | CN | disclosed |
| EP-0354994-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-02-21 | — | — | EP | disclosed |
| CN-1039416-A | Quinoline and preparation thereof and purposes | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1990-02-07 | — | — | CN | disclosed |