Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | CES2 | O00748 | 3/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8835492 | 0.78 | LMNA (0.38) | LMNACES2CES1KDM4EALDH1A1 | |
| SCHEMBL8542240 | 0.76 | CES2 (0.35) | LMNACES2KDM4EALDH1A1MAPK1 | |
| SCHEMBL680608 | 0.74 | LMNA (0.52) | LMNACES2CES1KDM4EALDH1A1 | |
| SCHEMBL28264518 | 0.72 | LMNA (0.46) | LMNACES2CES1KDM4EALDH1A1 | |
| SCHEMBL9817968 | 0.72 | LMNA (0.46) | LMNACES2CES1KDM4EALDH1A1 | |
| SCHEMBL545347 | 0.71 | LMNA (0.52) | LMNACES2CES1KDM4EALDH1A1 | |
| SCHEMBL28956589 | 0.69 | CES2 (0.50) | LMNACES2CES1KDM4EALDH1A1 | |
| SCHEMBL3516962 | 0.69 | LMNA (0.49) | LMNACES2CES1KDM4EALDH1A1 | |
| SCHEMBL8671236 | 0.68 | LMNA (0.41) | LMNACES2CES1KDM4EALDH1A1 | |
| SCHEMBL1476486 | 0.68 | CES2 (0.52) | LMNACES2CES1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |