Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 7/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.56 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.53 |
| ▸ | SELL | P14151 | 1/20 | 0.50 |
| ▸ | SELP | P16109 | 1/20 | 0.50 |
| ▸ | CFD | P00746 | 2/20 | 0.47 |
| ▸ | F11 | P03951 | 2/20 | 0.47 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | RXRB | P28702 | 3/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846040 | 0.88 | PTGER1 (0.64) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8846043 | 0.86 | FFAR1 (0.48) | PTGER1PTGER4PTGER3PTGER2FFAR1 | |
| SCHEMBL8845334 | 0.86 | RXRB (0.46) | FFAR1CFDF11TPSB2PLG | |
| SCHEMBL8846127 | 0.83 | CFD (0.53) | PTGER1PTGER4PTGER3PTGER2CFD | |
| SCHEMBL8846090 | 0.83 | RARB (0.65) | PTGER1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8845921 | 0.83 | PTGER1 (0.54) | PTGER1RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8846492 | 0.82 | RARB (0.49) | PTGER1PTGER4PTGER3PTGER2FFAR1 | |
| SCHEMBL8845935 | 0.82 | PTGER1 (0.48) | PTGER1PTGER4PTGER3PTGER2FFAR1 | |
| SCHEMBL8846554 | 0.81 | RXRA (0.46) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8525570 | 0.81 | RARG (0.53) | PTGER1PTGER4PTGER3PTGER2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | claimed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | claimed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | claimed |
| EP-0664282-B1 | Biaryl phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0664282-A1 | Biaryl phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5391817-A | Antiinflammatory agents | BRISTOL-MYERS SQUIBB (US) | 1995-02-21 | — | — | US | disclosed |