SCHEMBL8845356

SCHEMBL8845356

CC(C)c1cc(Oc2ccccc2)cc(C(C)C)c1N=C=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 1/20 0.41
MCL1 Q07820 1/20 0.41
PTGS1 P23219 1/20 0.39
LTA4H P09960 3/20 0.38
TSHR P16473 1/20 0.38
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CYP2D6 P10635 1/20 0.35
GABRA1 P14867 1/20 0.35
GABRB2 P47870 1/20 0.35
PTGES O14684 1/20 0.35
GSTP1 P09211 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
ALOX12 P18054 1/20 0.34
HTT P42858 1/20 0.34
ALOX5 P09917 1/20 0.34
MMP9 P14780 1/20 0.34
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8845542 0.87 LTA4H (0.40) BCL2MCL1PTGS1LTA4HTSHR
SCHEMBL9368279 0.84 BCL2 (0.41) BCL2MCL1PTGS1LTA4HTSHR
SCHEMBL9702653 0.84 BCL2 (0.38) BCL2MCL1PTGS1LTA4HTSHR
SCHEMBL2764978 0.80 BCL2 (0.35) BCL2MCL1PTGS1LTA4HTSHR
SCHEMBL7167416 0.79 GABRA1 (0.38) KMT2AGABRA1GABRB2HTT
SCHEMBL28972044 0.78 BCL2 (0.39) BCL2MCL1PTGS1LTA4HTSHR
SCHEMBL20692165 0.74 ALOX15 (0.33) MEN1KMT2AGABRA1GABRB2ALDH1A1
SCHEMBL8845381 0.74 ESR1 (0.40) MEN1KMT2AGABRA1GABRB2ALDH1A1
SCHEMBL191769 0.74 GABRA1 (0.50) PTGS1TSHRKMT2AGABRA1GABRB2
SCHEMBL221941 0.74 CA1 (0.43) GABRA1GABRB2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113024428-A Synthetic method of novel thiourea diafenthiuron for killing insects and mites 江苏长青农化股份有限公司 2021-06-25 CN claimed
CN-113023694-A Method for producing hydroxylamine hydrochloride by continuous method 江苏长青农化股份有限公司 2021-06-25 CN disclosed
CN-113024428-A Synthetic method of novel thiourea diafenthiuron for killing insects and mites 江苏长青农化股份有限公司 2021-06-25 CN disclosed
US-5654479-A USEFUL AS STABILIZERS AGAINST HYDROLYTIC DEGRADATION OF POLYADDITION AND POLYCONDENSATION PRODUCTS CONTAINING ESTER GROUPS BASF AKTIENGESELLSCHAFT (DE) 1997-08-05 US disclosed
US-5621138-A 4-PHENYL-2,6-DIISOPROPYLPHENYL ISOCYANATE BASF AKTIENGESELLSCHAFT (DE) 1997-04-15 US disclosed
EP-0597382-B1 Bis-(4-substituted-2,6-diisopropylphenyl)-carbodiimides, process for their preparation and their use and the intermediates for their preparation 4-substituted-2,6-diisopropyl phenylisocyanate BASF AG (DE) 1996-07-17 EP disclosed
US-5532414-A STABILIZATION AGAINST HYDROLYTIC DEGRADATION BASF AKTIENGESELLSCHAFT (DE) 1996-07-02 US disclosed
EP-0597382-A1 Bis-(4-substituted-2,6-diisopropylphenyl)-carbodiimides, process for their preparation and their use and the intermediates for their preparation 4-substituted-2,6-diisopropyl phenylisocyanate BASF Aktiengesellschaft (DE) 1994-05-18 EP disclosed