Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2456236 | 0.93 | PRKDC (0.41) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E | |
| SCHEMBL29375169 | 0.93 | PRKDC (0.41) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E | |
| SCHEMBL5707975 | 0.91 | MAPT (0.38) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E | |
| SCHEMBL2417015 | 0.91 | PRKDC (0.40) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E | |
| SCHEMBL7480012 | 0.90 | ALDH1A1 (0.39) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E | |
| SCHEMBL12205748 | 0.89 | PRKDC (0.39) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E | |
| SCHEMBL14607589 | 0.88 | POLB (0.40) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E | |
| SCHEMBL12259684 | 0.87 | PRKDC (0.39) | LMNASMN1; SMN2PRKDCKDM4ETDP1 | |
| SCHEMBL8845391 | 0.87 | CCR3 (0.37) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E | |
| SCHEMBL7471010 | 0.86 | NPSR1 (0.37) | LMNASMN1; SMN2L3MBTL1PRKDCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5623005-A | NAPTHOPYRAN COMPOUNDS CONTAINING AMINE SUBSTITUTION AT 6-POSITION; USEFUL TO MAKE OPHTHALMIC LENS | PILKINGTON PLC (GB) | 1997-04-22 | — | — | US | claimed |
| EP-0691965-B1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PILKINGTON PLC (GB) | 1996-12-04 | — | — | EP | claimed |