Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.39 |
| ▸ | HTR2B | P41595 | 9/20 | 0.39 |
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8846262 | 0.84 | ACHE (0.43) | HTR2CHTR2BHTR2AALDH1A1L3MBTL1 | |
| SCHEMBL8845748 | 0.84 | DRD4 (0.36) | HTR2CHTR2BHCRTR2 | |
| SCHEMBL8845546 | 0.66 | ITGB3 (0.48) | ALDH1A1 | |
| SCHEMBL8845742 | 0.66 | TP53 (0.35) | HTR2CHTR2BHTR2AHCRTR2 | |
| SCHEMBL30376197 | 0.65 | PARP10 (0.43) | ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL29374038 | 0.63 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6636318 | 0.62 | HRH1 (0.43) | ALDH1A1L3MBTL1 | |
| SCHEMBL6638799 | 0.62 | HRH1 (0.43) | ALDH1A1L3MBTL1 | |
| SCHEMBL8282497 | 0.61 | NPC1 (0.57) | ALDH1A1NAAA | |
| SCHEMBL6801884 | 0.60 | ROCK1 (0.47) | ALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688816-A | COGNITION ACTIVATOR; ALZHEIMER'S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-18 | — | — | US | disclosed |
| US-5455245-A | Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5264442-A | For treating alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-23 | — | — | US | disclosed |
| EP-0471298-A1 | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-02-19 | — | — | EP | disclosed |