Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.62 |
| ▸ | ACHE | P22303 | 5/20 | 0.62 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845681 | 0.84 | BCHE (0.48) | BCHEACHEMAOAALDH1A1CNR2 | |
| SCHEMBL8539761 | 0.81 | ACHE (0.70) | BCHEACHEMAOAALDH1A1KDM4E | |
| SCHEMBL9500230 | 0.80 | BCHE (0.43) | BCHEACHEMAOAMEN1KMT2A | |
| SCHEMBL2846516 | 0.77 | BCHE (1.00) | BCHEACHEMAOAALDH1A1KDM4E | |
| SCHEMBL8845692 | 0.76 | BCHE (0.41) | BCHEACHEFAAH | |
| SCHEMBL8539754 | 0.75 | BCHE (1.00) | BCHEACHEMAOAALDH1A1KDM4C | |
| SCHEMBL8845676 | 0.75 | ACHE (0.43) | BCHEACHEALDH1A1MEN1KMT2A | |
| SCHEMBL8846198 | 0.73 | ACHE (0.61) | BCHEACHEMAOAKDM4CCNR2 | |
| SCHEMBL8539757 | 0.73 | ACHE (0.68) | BCHEACHEMAOAALDH1A1KDM4E | |
| SCHEMBL8543797 | 0.72 | BCHE (0.62) | BCHEACHEALDH1A1KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688816-A | COGNITION ACTIVATOR; ALZHEIMER'S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0471298-B1 | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST ROUSSEL PHARMA (US) | 1995-11-02 | — | — | EP | disclosed |
| US-5455245-A | Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5264442-A | For treating alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-23 | — | — | US | disclosed |
| EP-0471298-A1 | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-02-19 | — | — | EP | disclosed |