Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 2/20 | 0.34 |
| ▸ | REN | P00797 | 3/20 | 0.33 |
| ▸ | BCL9 | O00512 | 3/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884721 | 0.90 | PTGIR (0.32) | PTGIRBCL9CTNNB1NPC1TP53 | |
| SCHEMBL884465 | 0.90 | KMT2A (0.37) | PTGIRRENBCL9CTNNB1ALDH1A1 | |
| SCHEMBL884782 | 0.87 | REN (0.38) | RENBCL9CTNNB1ALDH1A1CYP2C19 | |
| SCHEMBL2062532 | 0.87 | HTR1A (0.38) | PTGIRBCL9CTNNB1TSHRALDH1A1 | |
| SCHEMBL885548 | 0.86 | BCL9 (0.36) | RENBCL9CTNNB1ALDH1A1CYP2C19 | |
| SCHEMBL885607 | 0.85 | ALDH1A1 (0.38) | TSHRALDH1A1CASP1CASP7MAPT | |
| SCHEMBL884801 | 0.84 | HTR1A (0.37) | PTGIRRENBCL9CTNNB1TSHR | |
| SCHEMBL884402 | 0.84 | PTGIR (0.36) | PTGIRRENBCL9CTNNB1TSHR | |
| SCHEMBL884626 | 0.84 | PKM (0.42) | BCL9CTNNB1TSHRALDH1A1USP2 | |
| SCHEMBL2063592 | 0.84 | MEN1 (0.38) | PTGIRBCL9CTNNB1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089005-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-24 | — | — | WO | disclosed |