Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847204 | 0.83 | ABCC9 (0.50) | ALDH1A1HTTNPC1RAB9A | |
| SCHEMBL9794436 | 0.73 | MAPT (0.50) | KMT2AALDH1A1HTTMAPTNPC1 | |
| SCHEMBL8866390 | 0.72 | ABCC9 (0.70) | KMT2AMEN1 | |
| SCHEMBL28038778 | 0.72 | KMT2A (0.66) | KMT2AHSD17B14TLR7ALDH1A1CES2 | |
| SCHEMBL27314373 | 0.72 | TLR7 (0.70) | KMT2AHSD17B14TLR7ALDH1A1MEN1 | |
| SCHEMBL6564996 | 0.70 | KMT2A (0.54) | KMT2AHSD17B14ALDH1A1MEN1HTT | |
| SCHEMBL29560650 | 0.70 | KMT2A (0.72) | KMT2AHSD17B14TLR7ALDH1A1MEN1 | |
| SCHEMBL29485021 | 0.70 | KMT2A (0.72) | KMT2AHSD17B14ALDH1A1MEN1CES2 | |
| SCHEMBL743166 | 0.70 | KMT2A (0.72) | KMT2AHSD17B14ALDH1A1MEN1CES2 | |
| SCHEMBL17842342 | 0.70 | KMT2A (0.72) | KMT2AHSD17B14TLR7ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641302-B1 | ALCOHOLS AS POTASSIUM CHANNEL OPENERS AND IN TREATMENT OF URINARY INCONTINENCE | ZENECA LTD (GB) | 1997-12-10 | — | — | EP | disclosed |
| US-5411973-A | Potassium channel openers, urinary incontinence | ZENECA LIMITED (GB) | 1995-05-02 | — | — | US | disclosed |
| EP-0641302-A1 | ALCOHOLS AS POTASSIUM CHANNEL OPENERS AND IN TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023358-A1 | ALCOHOLS AS POTASSIUM CHANNEL OPENERS AND IN TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1993-11-25 | — | — | WO | disclosed |