Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 8/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 8/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 8/20 | 0.50 |
| ▸ | KCNJ8 | Q15842 | 8/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739253 | 0.84 | HTT (0.52) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL9794436 | 0.84 | MAPT (0.50) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8847220 | 0.83 | KMT2A (0.50) | ALDH1A1HTTNPC1RAB9A | |
| SCHEMBL8846776 | 0.78 | HSD11B1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL1744898 | 0.74 | ALDH1A1 (0.64) | ALDH1A1SRD5A2NPC1HPGDRAB9A | |
| SCHEMBL10411918 | 0.73 | ALDH1A1 (0.61) | ALDH1A1ELANESRD5A2NPC1HPGD | |
| Benzophenone SCHEMBL28321860 | 0.72 | ALDH1A1 (0.74) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL16582661 | 0.72 | ALDH1A1 (0.61) | ALDH1A1ELANESRD5A2NPC1HPGD | |
| SCHEMBL8525296 | 0.72 | NR1H2 (0.64) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL1637026 | 0.71 | L3MBTL1 (0.52) | PDK1PDK2PDK3PDK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641302-B1 | ALCOHOLS AS POTASSIUM CHANNEL OPENERS AND IN TREATMENT OF URINARY INCONTINENCE | ZENECA LTD (GB) | 1997-12-10 | — | — | EP | disclosed |
| US-5411973-A | Potassium channel openers, urinary incontinence | ZENECA LIMITED (GB) | 1995-05-02 | — | — | US | disclosed |
| EP-0641302-A1 | ALCOHOLS AS POTASSIUM CHANNEL OPENERS AND IN TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023358-A1 | ALCOHOLS AS POTASSIUM CHANNEL OPENERS AND IN TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1993-11-25 | — | — | WO | disclosed |